Cycloheximide production by Streptomyces griseus: control mechanisms of cycloheximide biosynthesis.
نویسنده
چکیده
Cycloheximide accumulation in a fermentation medium has been shown to be the product of the balance between synthesis and degradation of this antibiotic. Glucose has been shown to prevent cycloheximide degradation. Cycloheximide has been shown to interfere with its own synthesis probably due to feedback inhibition. Approaches for increasing cycloheximide titers in the light of these findings are discussed.
منابع مشابه
Changes in the protein profile of Streptomyces griseus during a cycloheximide fermentation.
The production of the antifungal agent cycloheximide by Streptomyces griseus is typical of many antibiotic fermentations. In the initial stage of the fermentation, cell growth is extensive, while little antibiotic is produced. After roughly 24 hours, the biomass concentration remains relatively constant and accumulation of product in the fermentation broth begins. It has been shown that product...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 7 6 شماره
صفحات -
تاریخ انتشار 1975